LRRK2 in Parkinson disease: challenges of clinical trials
Authors: Tolosa E, Vila M, Klein C, Rascol O
Journal: Nature Reviews Neurology
Reference: 16(2):97-107
Year: 2020
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Authors: Tolosa E, Vila M, Klein C, Rascol O
Journal: Nature Reviews Neurology
Reference: 16(2):97-107
Year: 2020
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Sex-dependent Calcium Hyperactivity Due to Lysosomal-Related Dysfunction in Astrocytes From APOE4 Versus APOE3 Gene Targeted Replacement Mice
Authors: Larramona-Arcas R, González-Arias C, Perea G, Gutiérrez A, Vitorica J, García-Barrera T, Gómez-Ariza JL, Pascua-Maestro R, Ganfornina MD, Kara E, Hudry E, Martinez-Vicente M, Vila M, Galea E, Masgrau R
Journal: Molecular Neurodegeneration
Reference: 15(1):35
Year: 2020
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Validation of a Reversed Phase UPLC-MS/MS Method to Determine Dopamine Metabolites and Oxidation Intermediates in Neuronal Differentiated SH-SY5Y Cells and Brain Tissue
Authors: Gonzalez-Sepulveda M, Laguna A, Carballo-Carbajal I, Galiano-Landeira J, Romero-Gimenez J, Cuadros T, Parent A, Peñuelas N, Compte J, Nicolau A, Guillard-Sirieix C, Xicoy H, Kobayashi J, Vila M.
Journal: ACS Chemical Neuroscience
Reference: 11(17):2679-87
Year: 2020
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Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis
Authors: Carballo-Carbajal I, Laguna A, Romero-Gimenez J, Cuadros T, Bové J, Martinez-Vicente M, Parent A, Gonzalez-Sepulveda M, Peñuelas N, Torra A, Rodriguez-Galvan B, Ballabio A, Hasegawa T, Bortolozzi A, Gelpi E, Vila M
Journal: Nature Communications
Reference: 10(1):973
Year: 2019
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Intracellular crowding by age-dependent neuromelanin accumulation disrupts neuronal proteostasis and triggers Parkinson disease pathology
Authors: Vila M, Laguna A, Carballo-Carbajal I
Journal: Autophagy
Reference: 15(11):2028-2030
Year: 2019
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Neuromelanin, aging and neuronal vulnerability in Parkinson’s disease
Authors: Vila M
Journal: Movement Disorders
Reference: 34(10): 1440-1451
Year: 2019
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Parkinson disease, substantia nigra vulnerability, and calbindin expression: Enlightening the darkness?
Authors: Blesa J, Vila M.
Journal: Movement Disorders
Reference: 34(2):161-163
Year: 2019
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Defective mitochondrial protein import contributes to complex I-induced mitochondrial dysfunction and neurodegeneration in Parkinson’s disease
Authors: Franco-Iborra S, Cuadros T, Parent A, Romero-Gimenez J, Vila M*, Perier C*
Journal: Cell Death & Disease
Reference: 9(11):1122
Year: 2018
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Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons
Authors: Urrea L, Segura-Feliu M, Masuda-Suzukake M, Hervera A, Pedraz L, Aznar JM, Vila M, Samitier J, Torrents E, Ferrer I, Gavín R, Hagesawa M, Del Río JA
Journal: Molecular Neurobiology
Reference: 55(3):1847-1860
Year: 2018
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Lack of pathogenic potential of peripheral α-synuclein aggregates from Parkinson’s disease patients
Authors: Recasens A, Carballo-Carbajal I, Parent A, Bové J, Gelpi E, Tolosa E, Vila M.
Journal: Acta Neuropathologica Communications
Reference: 6(1):8
Year: 2018
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Mitochondrial Quality Control in Neurodegenerative Diseases: Focus on Parkinson’s disease and Huntington’s disease
Authors: Franco-Iborra S, Vila M*, Perier C*
Journal: Frontiers in Neuroscience
Reference: 12:342
Year: 2018
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Overexpression of TFEB drives a pleiotropic neurotrophic effect and prevents Parkinson’s disease-related neurodegeneration
Authors: Torra A, Parent A, Cuadros T, Rodríguez-Galván B, Ruiz-Bronchal E, Ballabio A, Bortolozzi A, Vila M*, Bové J*
Journal: Molecular Therapy
Reference: 26(6):1552-1567
Year: 2018
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Selective alpha-Synuclein Knockdown in Monoamine Neurons by Intranasal Oligonucleotide Delivery: Potential Therapy for Parkinson disease
Authors: Alarcón-Arís D, Recasens A, Galofré M, Carballo-Carbajal I, Zacchi N, Ruiz-Bronchal E, Pavia-Collado R, Chica R, Ferrés-Coy A, Santos M, Revilla R, Montefeltro A, Fariñas I, Artigas F, Vila M*, Bortolozzi A*
Journal: Molecular Therapy
Reference: 26(2):550-567
Year: 2018
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Synaptic regulator α-synuclein in dopaminergic fibers is essentially required for the maintenance of subependymal neural stem cells
Authors: Perez-Villalba A, Salomé Sirerol-Piquer M, Belenguer G, Soriano-Cantón R, Belén Muñoz-Manchado A, Villadiego J, Alarcón-Arís D, Soria FN, Dehay B, Bezard E, Vila M, Bortolozzi A, José Toledo-Aral J, Pérez-Sánchez F, Fariñas I
Journal: Journal of Neuroscience
Reference: 38(4):814-825
Year: 2018
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The E3 ubiquitin-ligases TRIM17 and TRIM41 modulate α-synuclein expression by regulating ZSCAN21
Authors: Lassot I, Mora S, Lesage S, Zieba B, Coque E, Condroyer C, Bossowski JP, Mojsa B, Marelli C, Tesson C, Carballo-Carbajal I, Laguna A, Mangone G, Vila M, Brice A, Desagher S.
Journal: Cell Reports
Reference: 25(9):2484-2496.e9
Year: 2018
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The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity
Authors: 29. Kim H, Calatayud C, Guha S, Fernández-Carasa I, Berkowitz L, Carballo-Carbajal I, Ezquerra M, Fernández-Santiago R, Kapahi P, Raya A, Miranda-Vizuete A, Lizcano JM, Vila M, Caldwell KA, Caldwell GA, Consiglio A, Dalfo E
Journal: Molecular Neurobiology
Reference: 55(9):7553-7554
Year: 2018
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Cerebellar neurodegeneration in a new rat model of episodic hepatic encephalopathy
Authors: García-Lezana T, Oria M, Romero-Giménez J, Bové J, Vila M, Genescà J, Chavarria L and Cordoba J
Journal: Journal of Cerebral Blood Flow and Metabolism
Reference: 37(3):927-937
Year: 2017
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Glucocerebrosidase deficiency in dopaminergic neurons induces microglial activation without neurodegeneration
Authors: Soria FN, Engeln M, Martinez-Vicente M, Glangetas C, Lopez-Gonzalez MJ, Dovero S, Dehay B, Normand E, Vila M, Favereaux A, Georges F, Lo Bianco C, Bezard E, Fernagut Po
Journal: Human Molecular Genetics
Reference: 26(14):2603-2615
Year: 2017
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Alpha-synuclein propagation: New insights from animal models
Authors: Dehay B, Vila M, Bezard E, Brundin P, Kordower JH
Journal: Movement Disorders
Reference: 31(2):161-8
Year: 2016
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Functional rescue of dopaminergic neuron loss in Parkinson’s disease mice after transplantation of hematopoietic stem and progenitor cells.
Authors: Altarche-Xifro W, di Vicino U, Muñoz-Martin MI, Bortolozzi A, Bové J, Vila M, Cosma MP
Journal: EBioMedicine
Reference: 8:83-95
Year: 2016
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Authors: Klionsky DJ, Vila M et al
Journal: Autophagy
Reference: 12(1):1-222
Year: 2016
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The Parkinson disease mitochondrial hypothesis: where are we at?
Authors: Franco-Iborra S, Vila M, Perier C
Journal: Neuroscientist
Reference: 22(3):266-77
Year: 2016
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Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson disease patients
Authors: Fernández-Santiago R, Carballo-Carbajal I, Castellano G, Torrent R, Richaud Y, Sánchez-Danés A, Vilarrasa R, Sánchez-Pla A, Mosquera JL, Soriano J, López-Barneo J, Canals JM, Alberch J, Raya A, Vila M, Consiglio A, Martín-Subero JI, Ezquerra M, Tolosa E
Journal: EMBO Molecular Medicine
Reference: 7(12):1529-46
Year: 2015
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Targeting α-synuclein for treating Parkinson’s disease: mechanistic and therapeutic considerations
Authors: Dehay B, Bourdenx M, Gorry P, Przedborski S, Vila M, Hunot S, Singleton A, Olanow CW, Merchant KM ,Bezard E, Petsko GA, Meissner WG
Journal: Lancet Neurology
Reference: 14(8):855-66
Year: 2015
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BAX channel activity mediates lysosomal disruption linked to Parkinson disease
Authors: Bové J, Martínez-Vicente M., Dehay B, Perier C, Recasens A, Bombrun A, Antonsson B, Vila M
Journal: Autophagy
Reference: 10(5):889-900
Year: 2014
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DYRK1A promotes dopaminergic neuron survival in the developing brain and in a mouse model of Parkinson’s disease
Authors: Barallobre MJ, Perier C, Bové J, Laguna A, Delabar JM, Vila M, Arbonés ML
Journal: Cell Death & Disease
Reference: 5:e1289
Year: 2014
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Lewy Body extracts from Parkinson’s Disease Brains trigger α-Synuclein Pathology and Neurodegeneration in Mice and Monkeys
Authors: Recasens A, Dehay B, Bové J, Carballo-Carbajal I, Dovero S, Pérez A, Fernagut PO, Blesa J, Parent A, Perier C, Fariñas I, Obeso JA, Bezard E, Vila M
Journal: Annals of Neurology
Reference: 75(3): 351-62
Year: 2014
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Accumulation of mitochondrial DNA deletions within dopaminergic neurons triggers neuroprotective mechanisms
Authors: Perier C, Bender A, García-Arumí E, Melià MJ, Bové J, Laub C, Klopstock T, Elstner M, Mounsey RB, Teismann P, Prolla T, Andreu AL, Vila M
Journal: Brain
Reference: 136:2369-78
Year: 2013
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Alpha-synuclein and protein degradation pathways in Parkinson’s disease: A pathological feed-back loop
Authors: Martinez-Vicente M, Vila M
Journal: Experimental Neurology
Reference: 247:308-13
Year: 2013
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Lysosomal impairment in Parkinson’s disease
Authors: Dehay B, Martinez-Vicente M, Caldwell GA, Caldwell KA, Yue Z, Cookson MR, Klein C, Vila M, Bezard E
Journal: Movement Disorders
Reference: 28(6)725-32
Year: 2013
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Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency
Authors: Ramonet D, Perier C, Recasens A, Dehay B, Bové J, Costa V, Scorrano L, Vila M.
Journal: Cell Death & Differentiation
Reference: 20(1):77-85
Year: 2013
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Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson’s disease
Authors: Sánchez-Danés A, Richaud-Patin Y, Carballo-Carbajal I, Jiménez-Delgado S, Gaig C, Mora S, Di Guglielmo C, Ezquerra M, Patel B, Giralt A, Canals JM, Memo M, Alberch J, López-Barneo J, Vila M, Cuervo AM, Tolosa E, Consiglio A, Raya A
Journal: EMBO Molecular Medicine
Reference: 4(5):380-95
Year: 2012
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Efficient Generation of A9 Midbrain Dopaminergic Neurons by Lentiviral Delivery of LMX1A in Human Embryonic Stem Cells and Induced Pluripotent Stem Cells
Authors: Sánchez-Danés A, Consiglio A, Richaud Y, Rodríguez-Pizà I, Dehay B, Edel M, Bové J, Memo M, Vila M, Raya A, Izpisua-Belmonte JC.
Journal: Human Gene Therapy
Reference: 23(1):56-69
Year: 2012
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Guidelines for the use and interpretation of assays for monitoring autophagy
Authors: Klionsky DJ, Vila M et al
Journal: Autophagy
Reference: 8(4):445-544
Year: 2012
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Loss of ATP13A2/PARK9 induces general lysosomal deficiency: implications for Parkinson’s disease
Authors: Dehay B, Ramirez A, Martinez-Vicente M, Perier C, Canron MH, Doudnikoff E, Vital A, Vila M, Klein C, Bezard E
Journal: Proceedings of the National Academy of Sciences USA
Reference: 109(24):9611-6
Year: 2012
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Lysosomal dysfunction in Parkinson disease: ATP13A2 gets into the groove
Authors: Dehay B, Martinez-Vicente M, Ramirez A, Perier C, Klein C, Vila M, Bezard E
Journal: Autophagy
Reference: 8(9):1389-91
Year: 2012
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Mitochondria and programmed cell death in Parkinson’s disease: apoptosis and beyond
Authors: Perier C, Bové J, Vila M
Journal: Antioxidants & Redox Signaling
Reference: 16(9):883-95
Year: 2012
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Mitochondrial biology and Parkinson’s disease
Authors: Perier C, Vila M
Journal: Cold Spring Harbor Perspectives in Medicine
Reference: 2(2):a009332
Year: 2012
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Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system
Authors: Xilouri M, Kyratzi E, Pitychoutis PM, Papadopoulou-Daifoti Z, Perier C, Vila M, Maniati M, Ulusoy A, Kirik D, Park DS, Wada K, Stefanis L
Journal: Human Molecular Genetics
Reference: 21(4):874-89
Year: 2012
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. Fighting neurodegeneration with rapamycin: mechanistic insights
Authors: Bové J, Martínez-Vicente M, Vila M
Journal: Nature Reviews Neuroscience
Reference: 12(8):437-52
Year: 2011
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Lysosomal membrane permeabilization in Parkinson’s Disease
Authors: Vila M, Bové J, Dehay B, Rodríguez-Muela N, Boya P
Journal: Autophagy
Reference: 7(1):98-100
Year: 2011
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Oligomeric α-synuclein is toxic in vivo
Authors: Vila M
Journal: Movement Disorders
Reference: 26(9):1616
Year: 2011
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Apoptosis inducing factor deficiency sensitizes dopaminergic neurons to parkinsonian neurotoxins
Authors: Perier C, Bové J, Dehay, B, Jackson-Lewis V, Rabinovitch P., Przedborski, S, Vila M
Journal: Annals of Neurology
Reference: 68:184-192
Year: 2010
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Pathogenic lysosomal depletion in Parkinson’s Disease
Authors: Dehay B, Bové J, Rodríguez-Muela N, Perier C, Recasens A, Boya P, Vila M
Journal: Journal of Neuroscience
Reference: 30(37):12535-12544
Year: 2010
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Selective noradrenergic vulnerability in alpha-synuclein transgenic mice
Authors: Sotiriou E, Vassilatis DK, Vila M, Stefanis L
Journal: Neurobiology of Aging
Reference: 31(12):2103-14
Year: 2010
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Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson’s disease
Authors: Hoang T, Choi DK, Nagai M, Wu DC, Nagata T, Prou D, Wilson GL, Vila M, Jackson-Lewis V, Dawson VL, Dawson TM, Chesselet MF, Przedborski S
Journal: Free Radical Biology and Medicine
Reference: 47(7):1049-56
Year: 2009
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Mitochondrial alterations in Parkinson’s disease: new clues
Authors: Vila M, Ramonet D, Perier C
Journal: Journal of Neurochemistry
Reference: 107:317-328
Year: 2008
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Molecular pathways of programmed cell death in experimental Parkinson’s disease
Authors: Vila M, Perier C
Journal: Parkinsonism & Related Disorders
Reference: 14 Suppl 2:S176-9
Year: 2008
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Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson’s disease
Authors: Perier C, Bove J, Wu DC, Jackson-Lewis V, Dehay B, Choi DG, Rathke-Hartlieb S, Bouillet P, Strasser A., Schulz JB, Przedborski S, Vila M
Journal: Proceedings of the National Academy of Sciences USA
Reference: 104(19):8161-6
Year: 2007
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Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson’s disease
Authors: Choi DK, Pennathur S, Perier C, Tieu K, Teismann P., Wu DC, Jackson-Lewis V, Vila M, Von Sattel JP, Heinecke JW, Przedborski S
Journal: Journal of Neuroscience
Reference: 25(28):6594-600
Year: 2005
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